LATE

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See also: late

English[edit]

Noun[edit]

LATE (uncountable)

  1. (pathology) Acronym of limbic-predominant age-related TDP-43 encephalopathy, a form of dementia.
    • 2019 June, Peter T Nelson et al., “Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report”, in Brain, volume 142, number 6, DOI:10.1093/brain/awz099, page 1503:
      We describe a recently recognized disease entity, limbic-predominant age-related TDP-43 encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a stereotypical TDP-43 proteinopathy in older adults, with or without coexisting hippocampal sclerosis pathology.
    • 2020 March, Daniel Ferreira, Agneta Nordberg, and Eric Westman, “Biological subtypes of Alzheimer disease: A systematic review and meta-analysis”, in Neurology, volume 94, number 10, DOI:10.1212/WNL.0000000000009058:
      The clinical entity LATE (limbic-predominant age-related TDP-43 encephalopathy) has recently emerged.
    • 2020 May 14, Doreen Görß, Ingo Kilimann, Martin Dyrba, Sascha Nitsch, Bernd Krause, and Stefan Teipel, “LATE: not every dementia is Alzheimer's disease”, in Der Nervenarzt, DOI:10.1007/s00115-020-00922-z:
      The framework of LATE would account for the pathogenetic impact of limbic TDP-43 proteinopathy as a driver of amnestic dementia, either together with comorbid typical AD changes or as a distinct feature.

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