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megakaryocyte (plural megakaryocytes)
- (anatomy) A large cell, found in bone marrow, responsible for the production of platelets.
- 1890, W. H. Howell, “Observations upon the occurrence, structure, and function of the giant cells of the marrow”, in Journal of Morphology, volume 4, page 118:
- These have been described as giant cells with budding nuclei (Bizzozero ); but it seems to me that they are worthy of a more distinctive name. I shall speak of them hereafter as megakaryocytes, or large nucleated giant cells, while the first class might be named polykaryocytes, or multinucleated giant cells.
- 1914, Wade H. Brown, “The histogenesis of blood platelets”, in Studies from the Rockefeller Institute for Medical Research, page 69:
- The evidence of formation of blood platelets from the megakaryocyte is conclusive. Except for the origin of platelets in the early embryo from a forerunner of the megakaryocyte, Wright recognizes no other source for blood platelets in mammals.
- 2012, Alan D. Michelson, Platelets, page 28:
- Under appropriate culture conditions, the megakaryocyte burst-forming cell can develop into 40 to 500 megakaryocytes within 1 week.