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neratinib (uncountable)

  1. A tyrosine kinase inhibitor under investigation for the treatment of breast cancer and other solid tumors.
    • 2015 June 20, Lei Zhou et al., “The roles of microRNAs in the regulation of tumor metastasis”, in Cell & Bioscience[1], volume 5, DOI:10.1186/s13578-015-0028-8:
      The overexpression of miR-630 in breast cancer cells that are resistant to HER-targeted drugs significantly restores the efficacy of those drugs (e.g., lapatinib, neratinib and afatinib), which indicates that miR-630 can be used as a diagnostic and predictive marker to gauge the treatment response to HER-targeted drugs.