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synaptotoxicity (uncountable)

  1. The quality of being synaptotoxic.
    • 2015 November 6, “The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy”, in PLOS ONE[1], DOI:10.1371/journal.pone.0142340:
      Compared with vehicle-treated controls, rapamycin protected against the tau-induced neuronal loss, synaptotoxicity, reactive microgliosis and astrogliosis, and activation of innate neuroimmunity.