auristatin

English

Noun

auristatin (plural auristatins)

1. Any of a family of particular antineoplastic agents
   • 2015 July 11, “Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy”, in PLOS ONE‎^[1], →DOI:

     Here, we examine the stability of a non-cleavable Amino-PEG6-based linker bearing the monomethyl auristatin D (MMAD) payload site-specifically conjugated at multiple positions on an antibody.