ophiobolin
Jump to navigation
Jump to search
English
[edit]Noun
[edit]ophiobolin (plural ophiobolins)
- Any of a class of phytotoxic metabolites produced by certain fungi of the genus Helminthosporium
- 2015 August 14, “Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells”, in PLOS ONE[1], :
- Negative control wells (12/96 per assay plate) contained cells treated with 1% DMSO (final concentration) and positive control wells (4/96 per assay plate) contained cells treated with the fungal toxin ophiobolin A (Sigma Aldrich) at 50 μM with 1% DMSO. Ophiobolin A is cytotoxic both to proliferating and quiescent GSCs. Relative ATP levels were measured 24 hours later using the CellTiter-Glo reagent (Promega) according to the manufacturer's instructions.