Definition from Wiktionary, the free dictionary
- (vulgar) A slightly less offensive version of "fuck you".
- "Go to hell". For instance, You'll just lie in your bed all day rather than help us? Well, screw you.
- "Go away". For instance, Screw you-- go annoy someone else!
- Expression of contempt. For instance, You think you can come to my house dressed like a slob? Well, screw you.