gladiolin

English

Etymology

gladioli +‎ -in

Noun

gladiolin (uncountable)

1. (medicine, organic chemistry) An antibiotic produced by the bacterium Burkholderia gladioli, with potential applications in treating tuberculosis.
   • 2017, Lijiang Song et al., “Discovery and biosynthesis of gladiolin: a Burkholderia gladioli antibiotic with promising activity against Mycobacterium tuberculosis”, in Journal of the American Chemical Society, →DOI, page 7974:

     Gladiolin is structurally related to etnangien, a highly unstable antibiotic from Sorangium cellulosum that is also active against Mycobacteria.

   • 2018, Christopher Perry, Jacob R. Sargeant, Lijiang Song, Gregory L. Challis, “Relative stereochemical assignment of C-33 and C-35 in the antibiotic gladiolin”, in Tetrahedron, →DOI, page 5150:

     The configuration of all but one of the stereogenic centers of gladiolin has previously been elucidated using a combination of NOESY NMR experiments and predictive sequence analysis of the polyketide synthase responsible for its assembly.

   • 2020, Helen Smith, Lona Alkhalaf, Józef Lewandowski, Greg Challis, Matthew Jenner, “Reconstitution of a split C-methylating module from the gladiolin trans-AT polyketide synthase”, in 3rd International Conference on Natural Products Discovery and Development in the Genomic Era:

     In this study, a previously uncharacterised trans-AT PKS subunit interface between a ketoreductase and a methyltransferase domain (KR/MT junction) is examined from the gladiolin trans-AT PKS.