defucosylated

English

Adjective

defucosylated (not comparable)

1. Having undergone defucosylation.
   • 2015 July 23, “Glycoengineered Monoclonal Antibodies with Homogeneous Glycan (M3, G0, G2, and A2) Using a Chemoenzymatic Approach Have Different Affinities for FcγRIIIa and Variable Antibody-Dependent Cellular Cytotoxicity Activities”, in PLOS ONE‎^[1], →DOI:

     It was previously reported that the lack of the core fucose from Fc N-glycans significantly enhances ADCC activity compared to defucosylated and conventional mAbs, and we observed this phenomenon for both SKBR-3 and BT-474 cells, excluding aglycosylated mAbs (mAb-PNGF).