frameshift
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English
[edit]Etymology
[edit]Noun
[edit]frameshift (countable and uncountable, plural frameshifts)
Verb
[edit]frameshift (third-person singular simple present frameshifts, present participle frameshifting, simple past and past participle frameshifted)
- To use a starting point for translating a series of nucleotides that is off by an amount not divisible by three, resulting in an entirely distinct set of codons.
- 2003, Jacques Lapointe, Lea Brakier-Gigras, Translation Mechanisms, →ISBN, page 354:
- Commonly, there are stimulatory signals in mRNA distinct from the shift site that greatly increase the level of frameshifting at the shift site.
- 2004, DNA and Cell Biology - Volume 23, page 702:
- Considering these costs, it seems likely that mechanisms may exist to stop frameshifted translation as soon as possible, depending on the frequency of occurrence.
- 2006, De-Shuang Huang, George William Irwin, Computational Intelligence and Bioinformatics, →ISBN:
- Ribosomal frameshifting at a particular site can yield two protein products from one coding sequence or one protein product from two overlapping open reading frames.