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- Insufficient alveolarization
- 2015 December 12, “Tracheal Aspirate Levels of the Matricellular Protein SPARC Predict Development of Bronchopulmonary Dysplasia”, in PLOS ONE, DOI:10.1371/journal.pone.0144122:
- Further study is needed to determine the value of SPARC as a biomarker or therapeutic target in BPD. Introduction Improved survival of very premature infants has been accompanied by an increased incidence of bronchopulmonary dysplasia (BPD), a chronic pulmonary disease characterized by hypoalveolarization and a requirement for supplemental oxygen for months or years.