idiotype

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English[edit]

Etymology[edit]

idio- +‎ type

Pronunciation[edit]

  • Hyphenation: i‧di‧o‧type
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Particularly: "Islamic Immunology, anyone?"

Noun[edit]

idiotype (plural idiotypes)

  1. (immunology) A characteristic shared by a group of immunoglobulin or T cell receptor molecules, based on the antigen binding specificity of their variable region
    • 2000 March 31, Valerie Kouskoff et al., “T Cell-Independent Rescue of B Lymphocytes from Peripheral Immune Tolerance”, in Science[1], volume 287, number 5462, DOI:10.1126/science.287.5462.2501, pages 2501-2503:
      PD mice also lacked serum Ig of 3-83 specificity (3-83 idiotype).
    • 1997 October 10, Fotini Papavasiliou et al., “V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses”, in Science[2], volume 278, number 5336, DOI:10.1126/science.278.5336.298, pages 298-301:
      [] we stained µ i/ i/ B cells and controls with the Ac146, an antibody that recognizes the idiotype produced by the V B1-8 DJ H - V 3-83 J replacement combination (19 ).

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