idiotype

From Wiktionary, the free dictionary
Jump to navigation Jump to search

English

[edit]

Etymology

[edit]

From idio- +‎ type.

Pronunciation

[edit]
  • (US) IPA(key): /ˈɪ.diː.oʊ.taɪp/
  • Hyphenation: i‧di‧o‧type
  • Audio (US):(file)
  • Audio (Southern England):(file)

Noun

[edit]

idiotype (plural idiotypes)

  1. (immunology) A characteristic shared by a group of immunoglobulin or T-cell receptor molecules, based on the antigen-binding specificity of their variable region; and thus, the resultant immunologic phenotype, which can often be specific to a person or to only a small percentage of people.
    • 2000 March 31, Valerie Kouskoff et al., “T Cell-Independent Rescue of B Lymphocytes from Peripheral Immune Tolerance”, in Science[1], volume 287, number 5462, →DOI, pages 2501–2503:
      PD mice also lacked serum Ig of 3-83 specificity (3-83 idiotype).
    • 1997 October 10, Fotini Papavasiliou et al., “V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses”, in Science[2], volume 278, number 5336, →DOI, pages 298–301:
      [] we stained µ i/ i/ B cells and controls with the Ac146, an antibody that recognizes the idiotype produced by the V B1-8 DJ H - V 3-83 J replacement combination (19 ).

Derived terms

[edit]

Translations

[edit]

See also

[edit]