From malti- (representing Malte(se)) + poo(dle).
maltipoo (plural maltipoos)
- A dog that is a cross between a Maltese and a miniature poodle.
2005, Margaret H. Bonham, The Complete Idiot's Guide to Designer Dogs, OCLC 60327584, page 88:
Maltipoos are a cross between Maltese and Toy or Miniature Poodles. Their coat might be more like a Poodle's or a Maltese's, or somewhere in between.
2015 August 22, Rosanna Greenstreet, “Q&A: Rita Ora”, in The Guardian:
[What is your most treasured possession?] My new dog, Cher. She’s a maltipoo.