Blend of nigga + -izzle. Popularized by the hip-hop culture in 1990s and 2000s, as a rhyme of shizzle, as in fo shizzle my nizzle (“for sure, my nigga”).
nizzle (plural nizzles)
- (slang, US, African American Vernacular) Nigga, nigger.
See the usage notes at nigger and nigga.