nociplastic

English

Etymology

Blend of nociceptive +‎ neuroplastic, or perhaps noci- + plastic.

Adjective

nociplastic (not comparable)

1. (physiology) Of, pertaining to, or resulting from plasticity, of a kind analogous to neuroplasticity, in parts of the central nervous system concerned with nociception.
   • 2021, Deeba Minhas, Daniel Joseph Clauw, “Pain Mechanisms in Patients with Rheumatic Diseases”, in Maripat Corr, editor, Pain in Rheumatic Diseases, Elsevier, unnumbered page:

     Patients with rheumatic conditions often have mixed pain states, with varying degrees of nociceptive, neuropathic, and nociplastic mechanisms, which exist on a continuum. When individuals with any chronic pain have a nociplastic component to their symptoms, they are less likely to respond to treatments (eg, injections, surgery, biologics, and opioids) that work better for acute or purely nociceptive pain.

   • 2023, George Deng, “9: Fibromyalgia”, in Brian W. Blakley, Joan E. Blakley, editors, Functional Illness of the Head and Neck, Springer, page 75:

     Pain can be classified as nociceptive, neuropathic, or nociplastic as per the International Association for the Study of Pain [6, 7]. Fibromyalgia falls within the nociplastic classification.

   • 2024, Elaine Atkins, Emily Goodlad, Sharon Braddock, A Practical Approach to Musculoskeletal Medicine, 5th edition, Elsevier, page 5:

     Peripheral sensitisation of nociceptive neurons can enhance or prolong the pain experience, even without sensitisation of central neurons (i.e. nociplastic or central sensitisation).

Derived terms

• nociplastic pain

Related terms

• nociceptive
• nociplasticity

Translations

pertaining to or resulting from plasticity in the central nervous system

• French: nociplastique (fr)
• German: noziplastisch
• Italian: please add this translation if you can