synthetic lethality

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synthetic lethality (usually uncountable, plural synthetic lethalities)

  1. (genetics) A type of genetic interaction in which two (or more) mutations which are not lethal when occurring singly in a cell are lethal when they occur together in the same cell.


  • 2002, Maloy, Stanley; French-Mischo, Stephanie (2002), “Synthetic Lethal Mutations”, in Microbial Genetics[1] (in en), San Diego State University, archived from the original on 13 May 2003, retrieved 2009
  • Le Meur, Nolwenn; Gentleman, Robert (2008), “Modeling synthetic lethality”, in Genome Biology[2], volume 9, DOI:10.1186/gb-2008-9-9-r135, page R135