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- A surname.
- A village in Cumberland County, Illinois, United States.
- A small city, the county seat of Greenup County, Kentucky, United States.
- According to the 2010 United States Census, Greenup is the 27732nd most common surname in the United States, belonging to 867 individuals. Greenup is most common among White (74.16%) and Black/African American (13.84%) individuals.