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- An area and former region in Scotland, including Edinburgh.
- An unincorporated community in Anne Arundel County, Maryland, United States.
- A habitational surname.
- According to the 2010 United States Census, Lothian is the 50659th most common surname in the United States, belonging to 612 individuals. Lothian is most common among White (82.52%) and Black/African American (11.89%) individuals.