decernotinib

English

Noun

decernotinib (uncountable)

1. (pharmacology) An experimental medication belonging to the class of Janus kinase inhibitors.
   • 2021 December, Christine Liu, Jacqueline Kieltyka, Roy Fleischmann, Massimo Gadina, John J. O’Shea, “A Decade of JAK Inhibitors: What Have We Learned and What May Be the Future?”, in Arthritis & Rheumatology, volume 73, number 12, →DOI, page 2172:

     Developed to target the kinase domain of JAK3, decernotinib (VX-509) showed selective in vitro inhibition of JAK3 over the other JAKs and efficacy in RA (73, 74). However, a CYP3A4-mediated drug–drug interaction was also described, potentially limiting the use of decernotinib; development of this molecule has currently been halted (75).