hypergalactosylated
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English[edit]
Etymology[edit]
Adjective[edit]
hypergalactosylated (not comparable)
- Excessively galactosylated
- 2015 December 12, “Multi-Angle Effector Function Analysis of Human Monoclonal IgG Glycovariants”, in PLOS ONE[1], :
- We demonstrate a clear impact of glycosylation pattern on antibody stability and interaction with different FcγRs. Consistent with previous reports, deglycosylated antibodies failed to bind all Fcγ-receptors, with the exception of high affinity FcγRI. The FcγRII and FcγRIIIa binding activity of IgG1 was observed to depend on the galactosylation level, and hypergalactosylated antibodies demonstrated increased receptor interaction.