hypermannosylation
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English[edit]
Etymology[edit]
Noun[edit]
hypermannosylation (uncountable)
- Excessive mannosylation
- 2015 December 17, “Engineering of Immunoglobulin Fc Heterodimers Using Yeast Surface-Displayed Combinatorial Fc Library Screening”, in PLOS ONE[1], :
- The Fc variants contained two mutations (C228S and C231S) in the hinge region to exclude Fc homodimerization by eliminating the natural disulfide bonds in the hinge region and an N297Q mutation to avoid yeast hypermannosylation by removing the N-linked glycosylation site in the CH2 domain.