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- Having an immune system that has never been exposed to a specific antigen.
- 2006, Institute of Medicine, Medical Follow-Up Agency, Committee on U.S. Military Malaria Vaccine, Battling Malaria, →ISBN:
- In Western Kenya, approximately 100 percent of immunologically naïve older infants and toddlers develop confirmed clinical malaria during high season.
- 2011, Lila Miller & Kate Hurley, Infectious Disease Management in Animal Shelters:
- Animals entering shelters are either (a) immunologically naïve and susceptible to infection and development of disease if exposed to pathogens; (b) already immune as a result of natural immunization (e.g., recovery from infection or disease) or previous vaccination; or (c) already infected, either showing clinical signs or possibly incubating disease and/or shedding the infectious organisms to other susceptible animals.
- 2015, Patrick R. Murray, Ken S. Rosenthal, & Michael A. Pfaller, Medical Microbiology, →ISBN, page 382:
- Viruses that cause persistent productive infections (e.g., cytomegalovirus, HIV) are a particular problem because the infected person is a continual source of virus that can be spread to immunologically naïve people.