long-term potentiation

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Alternative forms[edit]

  • long term potentiation
    1988 March 1, Nicoll, R. A.; Kauer, J. A.; Malenka, R. C., “The current excitement in long term potentiation”, in Neuron[1], page 97:


long-term potentiation ‎(uncountable)

  1. (neuroscience) A long-lasting (hours in vitro, weeks to months in vivo) increase, typically in amplitude, of the response of a postsynaptic neuron to a particular pattern of stimuli from a presynaptic neuron.
    • 1999, Matt Ridley, Genome, Harper Perennial 2004, p. 228:
      Long-term potentiation, like sea-slug learning, absolutely depends on a change in the properties of synapses, in this case the synapses between the inputting cells and the pyramidal cells.


Coordinate terms[edit]


  • Escobar, Martha L.; Derrick, Brian (2007), “Long-Term Potentiation and Depression as Putative Mechanisms for Memory Formation”, in Bermúdez-Rattoni, Federico, editor, Neural Plasticity and Memory[2], CRC Press: “Tim Bliss and Terje Lomo1,2 first reported the phenomenon of long-term potentiation (LTP), an increase in synaptic efficacy following synaptic activity, over 30 years ago. Since then, LTP has generated enormous interest....”