senolysis

English

Etymology

seno- +‎ -lysis.

Noun

senolysis (countable and uncountable, plural senolyses)

1. (medicine) The destruction of senescent cells, such as to alleviate age-related diseases.
   • 2020, Joanne Laycock, et al., 7: The Role of Chronic Kidney Disease in Ectopic Calcification, Elena Aikawa, Joshua D. Hutcheson (editors), Cardiovascular Calcification and Bone Mineralization, Springer (Humana Press), page 156,

     These strategies^{[to target senescent cells]} consist of senolysis, immune-mediated senescent cell clearance and SASP neutralisation.

   • 2022, Franziska Kellers, et al., Senescence-Associated Molecules and Tumor-Immune-Interactions as Prognostic Biomarkers in Colorectal Cancer, Arndt Hartmann, Luca Di Tommaso (editors), Rising Stars 2021: Pathology, Frontiers in Medicine, page 46,

     This immune cell-mediated senolysis seems to be facilitated via direct cell-cell contact inducing apoptosis and granule exocytosis.

   • 2023, Jan O. Nehlin, Chapter 7: Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction, Ufuk Çakatay, Mehmet Can Atayik (editors), Advances in Protein Chemistry and Structural Biology, Volume 135, Elsevier (Academic Press), page 224,

     Senolytics are compounds that target selectively senescent cells and induce their lysis, a process known as senolysis. Senescent cells are resistant to apoptosis because they have an increase[d] expression of pro-survival networks.

Related terms

• senolytic
• senotherapy

Translations

destruction of senescent cells

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See also

• apoptosis