spastizin

English

Noun

spastizin (uncountable)

1. (biochemistry) A protein, characteristic of spastic paraplegia, that mediates autophagic lysosome reformation
   • 2015 June 17, Jennifer Hirst et al., “Loss of AP-5 results in accumulation of aberrant endolysosomes: defining a new type of lysosomal storage disease”, in Human Molecular Genetics‎^[1], volume 24, →DOI:

     Antibodies used in this study include in-house antibodies against clathrin, AP-5 ζ (monoclonal antibody used for IF), µ5 and SPG11 monoclonal (4) and spastizin [PER antibody (49)] and commercial antibodies against spastizin (Atlas HPA035693), EEA1 (BD Transduction Labs E41120), LAMP1 (Abcam ab24170 and H4A3), CIMPR (2G11; Calbiochem 444105), AP-2 µ2 (AP50; BD Transduction Labs 611351), LC3 (4E12; MBL M152-3B), LBPA (Jean Gruenberg), CD63 (H5C6; BD Biosciences), tubulin (DM1A, Abcam ab7291) and actin (C4, Abcam ab3280).