- (biochemistry, pharmacology) Extreme sensitivity (of the body) to a chemical.
1997 October 3, Eric J. Nestler & George K. Aghajanian, “Molecular and Cellular Basis of Addiction”, in Science, volume 278, number 5335, DOI:10.1126/science.278.5335.58, pages 58-63:
- Because D 1 dopamine receptors are known to act through stimulatory heterotrimeric guanosine triphosphate-binding (G s ) proteins and activation of the cAMP pathway, up-regulation of this pathway in the nucleus accumbens could account for the functional supersensitivity of D 1 receptors observed in these neurons--which occurs in the absence of detectable changes in the receptors themselves--after chronic cocaine (or other stimulant) exposure (18 ).
1998 October 9, Zhen-Ming Pei et al., “Role of Farnesyltransferase in ABA Regulation of Guard Cell Anion Channels and Plant Water Loss”, in Science, volume 282, number 5387, DOI:10.1126/science.282.5387.287, pages 287-290:
- In the next generation seeds were screened for ABA supersensitivity (era1/era1).
1999 October 15, Mohammed Akaaboune et al., “Rapid and Reversible Effects of Activity on Acetylcholine Receptor Density at the Neuromuscular Junction in Vivo”, in Science, volume 286, number 5439, DOI:10.1126/science.286.5439.503, pages 503-507:
- The effects of inactivity on new receptor synthesis and denervation supersensitivity are mediated by Ca 2 influx (24 ).