- Acronym of Crown-of-Thorns Starfish.
- Acronym of Commercial Off-The-Shelf (Refers to ready-made merchandise that is available for sale, defined by market need, significant functionality and complexity, and self-contained.)
- Acronym of Consumer Off-The-Shelf (same as Commercial Off-The-Shelf.)
- (NASA, space science) Acronym of Commercial Orbital Transportation Services (program for delivery to the International Space Station by private companies)
- (Commercial/Consumer off-the-shelf): Mil-COTS