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- Acronym of crown-of-thorns starfish.
- Acronym of commercial/consumer off-the-shelf (Refers to ready-made merchandise that is available for sale, defined by market need, significant functionality and complexity, and self-contained.)
- (Commercial/Consumer off-the-shelf): Mil-COTS
- (NASA, space science) Acronym of Commercial Orbital Transportation Services (program for delivery to the International Space Station by private companies)