bandshift assay

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bandshift assay (plural bandshift assays)

  1. (biochemistry) A type of assay using gel electrophoresis, in which the mobility of a DNA or RNA probe alone is compared to its mobility in combination with a particular protein, so as to measure the degree and nature of binding between the protein and DNA or RNA.
    • 2001 May 11, Peter Baumann & Thomas R. Cech, “Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans”, in Science[1], volume 292, number 5519, DOI:10.1126/science.1060036, pages 1171-1175:
      In bandshift assays, hPot1p bound to the G-rich strand of human telomeric DNA.

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