chimeric antigen receptor

English

Noun

chimeric antigen receptor (plural chimeric antigen receptors)

1. (immunology) A receptor protein engineered to give T cells the (new) ability to attach to a specific target protein.

   Synonyms: CAR, chimeric immunoreceptor, chimeric T cell receptor, artificial T cell receptor

   • 2014, Connie Duong, Generation of Novel Chimeric Antigen Receptors to Enhance the Specificity and Activity of T Cells for the Adoptive Immunotherapy for Cancer, University of Melbourne:
   • 2020, Mumtaz Yaseen Balkhi, Basics of Chimeric Antigen Receptor (CAR) Immunotherapy, Elsevier (Academic Press):
   • 2021, Stela Petkova, Targeting and Elimination of T Cell Subpopulations by Chimeric Antigen Receptor-modified T Cells, Georg-August-Universität Göttingen:

Usage notes

Typically used once to introduce the term and subsequently abbreviated as CAR.

Derived terms

• CAR therapy
• CAR T cell
• chimeric antigen receptor T cell

Translations

type of engineered receptor protein

• French: please add this translation if you can
• German: chimärer Antigenrezeptor m