holdase (plural holdases)
- A particular kind of molecular chaperone that assists the non-covalent folding of proteins in an ATP-dependent manner. Holdases bind to protein folding intermediates to prevent their aggregation but without directly refolding them.
2015 July 28, Ohad Suss, Dana Reichmann, “Protein plasticity underlines activation and function of ATP-independent chaperones”, in Frontiers in Molecular Biosciences, volume 2, DOI:10.3389/fmolb.2015.00043:
- As a part of that network, holdase chaperones are able to communicate with other chaperones in the network, to achieve refolding of misfolded clients.