pyrophosphorylysis

English

Noun

pyrophosphorylysis (plural pyrophosphorylyses)

1. The cleavage of a nucleoside from a nucleotide by breaking the bond to the phosphate group by a reaction with pyrophosphorylase.
   • 1986, Patrick Sai-Cheong Leung, Cloning of the Salmonella Typhimurium LT2 Glycogen Biosynthetic Genes:

     The enzyme preparations were assay for ADPglucose pyrophosphorylase activity in the pyrophosphorylysis direction and were diluted to 0.5 units per ml with 50 mM Tris-HCl, pH 8.0, containing O. l mg/ml of bovine plasma pyrophosphorylase.

   • 2002, Advances in Virus Research - Volume 58, page 170:

     Increased pyrophosphorylysis means that newly incorporated nucleotides, including potentially chain-terminating nucleotide analogues, are excised at a higher rate.

   • 2017, Douglas L. Mayers, Jack D. Sobel, Marc Ouellette, Antimicrobial Drug Resistance, →ISBN:

     Although the DKAs and dihydroxypyrimidines can compete with nucleosides for binding to the active site, these compounds inhibit the pyrophosphorylysis (excision) of strand-terminating nucleosides once they are incorporated into the nascent HCV RNA.