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From the verb phrase screw up.
screwup (plural screwups)
- (colloquial) A substantial mistake, usually causing problems for more people than just the person or group who made it.
- 1977, John Osborne, White House watch: the Ford years, page 147:
- The Ford administration emerged in better shape than it deserved from the fantastic screw-up that preceded the release of the Rockefeller...
- (colloquial) A person who often makes substantial mistakes; a bungler.
- (colloquial) A person who is mentally or emotionally damaged.