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  1. plural of megrim
  2. Any of various diseases of animals, especially horses. (More at megrim.)
  3. (usually with "the") Depression, low spirits, unhappiness.
    • 1960, P. G. Wodehouse, Jeeves in the Offing, chapter XIII:
      I'm not myself, of course, an idealistic girl in love with a member of the staff of the Thursday Review and never have been, but if I were I know I'd get the megrims somewhat severely if I caught [my fiancé] in a clinch with anyone as personable as this stepdaughter of Aubrey Upjohn, for though shaky on the IQ, physically she was a pipterino of the first water.