uptitration
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English[edit]
Etymology[edit]
up- + titration; compare also upregulation and downregulation.
Noun[edit]
uptitration (usually uncountable, plural uptitrations)
- (medicine) The gradual increase of a dose accompanied by observation of effects, usually and especially to arrive at an optimal dose.
- 2015 July 13, Deena S Goldwater, Sean P Pinney, “Frailty in Advanced Heart Failure: A Consequence of Aging or a Separate Entity?”, in Clinical Medicine Insights. Cardiology[1], volume 9, :
- Somewhat counterintuitively, but perhaps due to indirect effects on the renin–angiotensin system, Scherer and colleagues (2013) found that appropriate uptitration of BBs improves HRQoL in elderly HF patients with reported benefits in general health, vitality, and physical function, although physical capacity was not objectively quantified. Regarding the renin–angiotensin–aldosterone system, as discussed above, administration of ACE inhibitors in normal aging may have a modest effect in slowing the progression of muscle-related weakness, although results are variable.