hepcidin

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English[edit]

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Etymology[edit]

From hep ‎(liver) +‎ -cide ‎(killing) +‎ -in ‎(compound), because of its origin and bacteria-killing properties.

Noun[edit]

hepcidin ‎(usually uncountable, plural hepcidins)

  1. A hormone produced by the liver that regulates iron homeostasis in mammals.
    • 2008, November 26, “Masako Kohyama, Wataru Ise, Brian T. Edelson, Peter R. Wilker, Kai Hildner, Carlo Mejia, William A. Frazier, Theresa L. Murphy, Kenneth M. Murphy”[Nature], Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis, volume 457, number 7227, DOI:10.1038/nature07472:
      The known genetic defects of iron metabolism 14, 25, 26 frequently involve proteins that function as iron transporters/exporters (for example, ferroportin 18), as receptors for iron-binding proteins (for example, transferrin receptor 27 and hemochtomatosis 28), or to regulate the activity of these transporters or receptors (for example, hepcidin 29).