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- (baseball) The base opposite home plate in a baseball infield.
- The runner slid into second base with a double.
- (singular only, US, colloquial) Touching a partner under his or her clothes, without having sex.
- 2011 November 3, “The Isolation Permutation”, in The Big Bang Theory, season 5, episode 8, spoken by Amy Farrah Fowler (Mayim Bialik):
- How about this? French kissing. Seven minutes in heaven, culminating in second base.
the base opposite home plate