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- (psychology) A severe mental disorder, sometimes with physical damage to the brain, marked by a deranged personality and a distorted view of reality.
- 2014 April 21, “Subtle effects”, in The Economist, volume 411, number 8884:
- Manganism has been known about since the 19th century, when miners exposed to ores containing manganese […] began to totter, slur their speech and behave like someone inebriated. The poisoning was irreversible, and soon ended in psychosis and death.