Definition from Wiktionary, the free dictionary
Jump to navigation Jump to search


Alternative forms[edit]


1894, US. lyo- +‎ philos +‎ -ization (alternatively analyzed as lyophilize +‎ -ation), from Ancient Greek λύω (lúō, to loosen, to dissolve) + φίλος (phílos, beloved) + -ίζειν (-ízein) + Latin -ātiō, due to the dried product being able to rapidly reabsorb the solvent and restore the original substance, hence “lyophil” (solvent-loving). Popularized from 1960 by Louis R. Rey.[1][2] Cognates in other European languages via same construction.


lyophilization (countable and uncountable, plural lyophilizations)

  1. freeze-drying; the removal of moisture from a frozen material using vacuum
    • 1894, United States Department of Agriculture, Crops in Peace and War: The Yearbook of Agriculture (U.S. G.P.O.), p. 74, p. 907:
      After dialysis, the enzyme can be obtained as a dry powder by lyophilization.
      Lyophilization The process of vacuum-drying substances from the frozen state. The water is sublimated into a trap at low temperature or is absorbed by drying agents. Verb: lyophilize.

Related terms[edit]



  1. ^ Lyophilized Biologics and Vaccines: Modality-Based Approaches, 2015, →ISBN, p. 5
  2. ^ New ventures in freeze drying, L. Rey, Nature, volume 345, pages 185–186 (10 May 1990), “Called lyophilization because it produces dry products that ‘love’ solvents (lyos-philein),”